الملخص
En adultos mayores, la ancylostomiasis tiene manifestaciones básicas como pérdida del apetito y masa muscular, evacuación excesiva, debilidad y otras que hacen propenso al adulto mayor a un estado de fragilidad, un tipo de síndrome de fallo multiorgánico crónico, donde interviene la disfunción de diversos sistemas. Este agravante fundamenta el objetivo de la presente investigación, centrado en identificar el comportamiento de los criterios clínicos, funcionales, mentales y sociodemográficos en la evaluación geriátrica del síndrome de fragilidad en adultos mayores parasitados por Ancylostoma spp. en el cantón Santiago de Píllaro. La muestra resultó integrada por un total de 102 adultos mayores a 65 años. Mediante la revisión de las historias clínicas y la aplicación de una encuesta a los participantes, se evaluó el comportamiento de los criterios sociodemográficos, médicos, funcionales, mentales y de comorbilidad asociada. Los datos obtenidos fueron procesados estadísticamente mediante análisis bivariado y regresión logística múltiple. Los factores estadísticamente asociados a la fragilidad fueron el sexo femenino (p= 0,003, IC 95% ,LI= 1,564 y LS= 8,950), los bajos ingresos económicos (p= 0,011, IC 95%: LI= 1,786 y LS= 7,433), la polifarmacia (p= 0,006, IC 95%: LI= 2,452 y LS= 14,415) ), las evacuaciones frecuentes (p=0,009, con IC95%: LI=2,704 y LS=7,536) y las afecciones bucodentales (p= 0,004, IC 95%: LI= 1,895 y LS= 6,572), por lo que se justifica la elaboración de estrategias y acciones de salud que minimicen los efectos del estado de fragilidad en la población estudiada(AU)
In older adults, ancylostomiasis has basic manifestations such as loss of appetite and muscle mass, excessive evacuation, weakness and others that make the older adult prone to a state of fragility, a type of chronic multi-organ failure syndrome, where dysfunction of various systems. This aggravating factor supports the objective of the present investigation, focused on identifying the behavior of the clinical, functional, mental and sociodemographic criteria in the geriatric evaluation of frailty syndrome in elderly adults parasitized by Ancylostoma spp. in the canton Santiago de Pillaro. The sample was made up of a total of 102 adults over 65 years of age. By reviewing the medical records and applying a survey to the participants, the behavior of the sociodemographic, medical, functional, mental and associated comorbidity criteria was evaluated. The data obtained were statistically processed using bivariate analysis and multiple logistic regression. The factors statistically associated with frailty were female sex (p = 0.003, 95% CI, LI = 1.564 and LS = 8.950), low income (p = 0.011, 95% CI: LI = 1.786 and LS = 7.433) , polypharmacy (p = 0.006, 95% CI: IL = 2.452 and LS = 14.415)), frequent bowel movements (p = 0.009, with 95% CI: IL = 2.704 and LS = 7.536) and oral disorders (p = 0.004 , 95% CI: LI = 1.895 and LS = 6.572), which is why the development of health strategies and actions that minimize the effects of the state of frailty in the population studied is justified(AU)
الموضوعات
Humans , Male , Female , Aged , Aged, 80 and over , Geriatric Assessment , Ancylostoma , Ancylostomiasis/diagnosis , Ancylostomiasis/etiology , Comorbidity , Logistic Models , Medical Records , Ecuador/epidemiologyالملخص
Methyl [5-[[4-(2-pyridinyl-1-piperazinyl] carbonyl]-1H- benzimidazol-2-yl] carbamate (CDRI Compound 81-470) exhibits a long prophylactic action against experimental ancylostomiasis, when given parenterally but not orally. To find out an explanation for such a behaviour, metabolic disposition studies were performed in hamsters using [3H] compound 81-470. Following intramuscular administration, the compound was found to form a depot at the site of injection and to remain there in substantial amount for more than 7 weeks. The compound was fairly distributed in all the organs studied and the presence of radioactivity could be easily detected up to 7 weeks of observation period. The compound was very slowly eliminated from the body and only 38% of the radioactivity could be recovered in the urine and faeces during 14 days. The oral dose, to the contrary, was poorly absorbed and more than 62.8% was excreted in the faeces within 48 hr. Consequently, this dose yielded lesser area under plasma curve. More than 95% of the oral dose was eliminated within a week and hardly and radioactivity could be detected in the tissues after day 14. In accord with this pattern, in blood also the im dose was detected up to 7 weeks while the orally given compound reached undetectable level within 6 days only. The lower clearance and prolonged stay in the body of the im dose compared to quick elimination of the oral dose may be responsible for the long chemoprophylactic action of compound 81-470 when given through im route.